加拿大多伦多大学附属儿童医院(SickKids)建立于1875年，是加拿大最大的集治疗、科研和教学为一体的儿童医院之一，也是在加拿大研究项目最为密集的医院之一，在北美儿童医院中排名前三。从1972年开始，医院楼顶设直升机起降坪供患者使用，是多伦多市中心仅有的两家拥有直升机起降坪的医院之一。

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About SickKids

Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. 

Our reputation would not have been built – nor could it be maintained – without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.

Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.

Position Description

The Genetics and Genome Biology Program at the Hospital for Sick Children (SickKids) Research Institute is seeking an enthusiastic postdoctoral researcher to work in close collaboration with research and clinician scientists in analyzing next generation sequencing data of individuals with genetic disorders.

With the direction of principal supervisor Dr. Ryan Yuen, you will work closely with affiliated staff, as well as bioinformaticians at SickKids, to study the genetics of neurodevelopmental and neurological disorders.

The Yuen lab (https://lab.research.sickkids.ca/yuen/) is developing and implementing new technologies and computational algorithms to perform genome-wide analysis of tandem repeats. Our aims are to genotype tandem repeats on large genomic datasets, as well as determine the role, and characterize the mechanism, of tandem repeat variation (e.g., Trost et al, 2020 Nature DOI: 10.1038/s41586-020-2579-z). 

The Yuen lab also performs whole genome sequence analysis to investigate different forms of rare genetic variation in neurodevelopmental and neurological disorders, such as autism spectrum disorder, movement disorders, epilepsy, and schizophrenia (e.g., Mojarad et al, 2021 Transl Psychiatry DOI: 10.1038/s41398-021-01211-2).

A substantial amount of data, and tools, already exist for these ongoing projects in the Yuen lab. The postdoctoral researcher will be able to jump straight into existing projects, and lead genome analyses.

Requirements

• PhD in a relevant area (e.g., genetics or computational biology).
• Track record of publishing scientific papers in top journals as a lead author.
• Excellent communication skills (oral and written).
• Be able to work independently and meet deadlines.
• Experience in the analysis of next generation sequencing data is preferred.
• Experience in programming (e.g., Python, R or Java) is preferred.
• Experience in clinical research would be an asset.

We offer

• Initial contract will be for a period of two years, with the possibility of extension.
• We offer a competitive salary based on qualifications and experience.
• In addition, we offer an attractive benefits package, that includes extended health and dental coverage.
• The Research Institute offers many opportunities for career development and additional training as part of the Research Training Centre.

Additional information

Contact Dr. Yuen at ryan.yuen@sickkids.ca for more information. If you wish to apply directly, please send a CV, a cover letter with your research interests, relevant background and career goals, and contact information for three references.

Our Commitment to Diversity

The children and families we care for are diverse, and so are our employees. All are welcome to join our unique organizational culture and be part of our inclusive team.

If requested, SickKids is proud to make available accommodations to support applicants with disabilities during the interview and assessment process. Information received relating to accommodation will be addressed confidentially. SickKids is also committed to providing services in both official languages and our preference is to hire employees who are fluent in both English and French whenever possible.

Thank you for your interest in joining SickKids. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at SickKids is conditional upon the Hospital’s receipt of all necessary documentation.