英国伯明翰大学（University of Birmingham），简称“伯大”，始建于1825年，位于英国第二大城市伯明翰，世界百强名校，世界一流研究型大学。伯大是英国顶尖学府，也是英国第一所红砖大学，曾于1900年获英国维多利亚女王授予的皇家特许状，也是罗素大学集团、M5大学联盟、全球大学高研院联盟核心成员，Universitas 21创始成员。
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Job Summary
We are looking for a talented and highly motivated scientist to join the lab of Dr Helen McGettrick in the Rheumatology Research Group with the Institute of Inflammation and Ageing. Our research is focused on understanding the cellular and molecular basis of immune mediated inflammatory diseases.
We have an exciting opening for an enthusiastic scientist to join our group and lead the experimental immunology and preclinical studies of a 10-month translational research project funded by our industry collaborators Dompé Pharmaceuticals.
The aim of the project is to investigate the therapeutic potential of compounds provided by Dompé in preclinical murine models of inflammatory arthritis. This research will predominantly involve the use of murine models of inflammatory arthritis and their associated analysis of tissues by immunohistochemistry/ immunofluorescence or flow cytometry, as well as immunoassays to detect the effector functions of leukocytes including NETosis.
The successful applicant will be based in the Rheumatology Research Group within the Institute of Inflammation and Ageing at the University of Birmingham and will join an enthusiastic team of scientists and academic clinicians. You will be expected to work in close collaboration with the scientific team at Dompé Pharmaceuticals.
You must hold a relevant PhD/DPhil (or near completion), together with relevant experience in murine models of inflammation and associated molecular and tissue analysis, and have a demonstrable track record in immunology, evidenced by first author publications in high quality, peer-reviewed journals. An understanding of the processes governing leukocyte trafficking in health and disease and having a personal licence to work with animals in the UK is essential. Experience and expertise in mouse models of inflammatory arthritis, immunohistochemistry and flow cytometry, and leukocyte biology is highly desirable.
You will manage your own academic research and administrative activities, this involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will adapt existing and develop new scientific techniques and experimental protocols and test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will use specialist scientific equipment in a laboratory environment and act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.
Please read the accompanying job description carefully and ensure that you address each selection criteria in a supporting statement which must be uploaded together with your CV when applying online. For further information please contact Dr Helen McGettrick: h.m.mcgettrick@bham.ac.uk. This is a fixed-term, full-time position for 10 months in the first instance.
Role overview The successful applicant will be responsible for leading the murine models of inflammatory arthritis, tissue analysis and molecular biology components of the project including functional analysis of neutrophil effector function (NETosis).
Main Duties and Responsibilities These key tasks are not intended to be exhaustive but simply highlight a number of major tasks which the staff member may be reasonably expected to perform.
• To perform scientific research, reviewing and refining working hypotheses, and developing and acquiring relevant skills.
• To analyse and interpret data, preparing and publishing your findings in peer-reviewed journals.
• To actively participate in the broader research team, working closely with clinical and experimental colleagues to share data and findings and help design experiments.
• To communicate results in regular meetings, by poster and oral presentations at scientific meetings, or via other suitable means.
• To identify training needs and to follow an agreed strategy to meet them.
• To act as a source of information and advice to other members of the group, training and supervise graduate and undergraduate students as appropriate.
• To keep abreast of the relevant literature and methodological developments and to contribute ideas for new research projects.
• To manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines.
Relationships
• The Postdoctoral Fellow will be a member of the Inflammation and Stromal Biology Team led by Dr Helen McGettrick at the Institute of Inflammation and Ageing.
• The post-holder will work closely with clinical and experimental colleagues in the research groups at Dompé Pharmaceuticals.
Person Specification
Essential:
• A personal licence to work with animals in the UK is essential
• A PhD/DPhil (or near completion) in a discipline of direct relevant to Rheumatology and/or Immunology.
• Degree-level training in immunology/biomedical sciences or equivalent experience.
• A passion for problem-solving and research in the areas of immunology or cell biology that is grounded in expert-level knowledge or experience.
• A successful track record with the statistical analysis and interpretation of experimental data.
• Highly motivated and able to use own initiative to solve problems.
• Excellent interpersonal skills, able to work independently and collaboratively.
• Excellent communication skills, both oral and written.
• Excellent organisational and project management skills, able to manage both time and records effectively.
• Good working knowledge of office software.
• Demonstrate an ability to follow departmental guidance in handling sensitive and personal information, including complying with current data protection legislation Desirable selection criteria.
• Experience with murine models of inflammatory arthritis and their analysis.
• Strong publication track record and experience of presenting work at meetings.
• Cross-disciplinary collaborative experience.
Job Information The Rheumatology Research Group in Birmingham (RRG) Our group is within the RRG which itself sits within the Institute of Inflammation and Ageing, one of seven research institutes in the College of Medical and Dental Sciences at the University of Birmingham. The RRG is a multidisciplinary team of academic and clinical rheumatologists, biological and social scientists, general practitioners, allied health professionals and patient representatives.
Informal enquires to Helen McGettrick (h.m.mcgettrick@bham.ac.uk)
