Both positions utilize cutting-edge interdisciplinary research and aim to understand abnormal vascular remodeling in pulmonary arterial hypertension (PAH) and other pulmonary vascular diseases.The Ke lab will dissect the critical role of pericytes during pulmonary vessel remodeling, by using a combination of cell-based models of angiogenesis, multiple novel inducible transgenic murine models, genome sequencing analysis, in addition to CRISPR gene editing toolkits, 3D spheroid models, precision-cut lung slicing technology, high-resolution deep tissue imaging, and single-cell RNA-seq.Our ultimate goal is to identify potential therapeutic targets that could be exploited for the development of new drugs capable of preventing abnormal vessel remodeling and obliteration in PAH.
Boston Children’s Hospital is ranked the #1 pediatric hospital in the nation by U.S. News and World Report. It is home to the world’s largest pediatric research enterprise, the leading recipient of pediatric research funding from the National Institutes of Health, and the primary pediatric teaching hospital for Harvard Medical School.
Who are we looking for:
Postdoctoral Research Fellow:
Highly motivated Ph.D. with a strong background in> The candidate must also have enthusiasm, excellent critical thinking skills, a track-record of productivity as demonstrated by at least> Prior experience with right ventricular pressure measurements in rodents, primary cell culture, bioinformatics (Single-cell sequencing, ChIP-seq) and data analysis, and CRISPR mediated genome editing would be an advantage.
Research Assistant:
Candidates with Bachelor’s or Master’s degree in Biomedical Sciences or related discipline, Animal handling are preferred; proper attention to details, excellent verbal and written communication skills are prerequisites; experience with rodents, molecular/cell biology, bioinformatics would be an advantage.
What will we offer you:
A successful candidate will have the opportunity to lead independent and cutting-edge research projects with a world-class research facility while obtaining valuable experience with the relevant technology that prepares well for future positions in academia or industry. We will also provide a customizable curriculum, individual career development/support, and Interdisciplinary and collaborative research community.
To apply, please send：
1）a cover letter with a brief statement of research experience and future proposed interests,
2）a detailed curriculum vitae to: Ke Yuan, Ph.D. FAHA
Assistant ProfessorParker B Francis Fellow
Department of Pediatrics
Boston Children’s Hospital/Harvard Medical School
300 Longwood Ave Enders 461.2, Boston, MA 02115
t: 1-617-355-0622
email:ke.yuan@childrens.harvard.edu
院校简介
波士顿儿童医院（Boston Children’s Hospital）是全球最好、美国最大的儿童医院，历年全美儿童医院综合排名第一。
小儿癌症历年稳居全美第一。此外，在儿童心脏、儿童神经、儿童骨科、儿童内分泌、儿童泌尿、儿童肺科等领域也稳居全美前两位。
波士顿儿童医院始于1869年，一家非盈利医疗机构。140年以来，一直在为儿童疾病的治疗而努力，从1947年首次成功缓解白血病到最近的复杂胎儿心脏缺陷的矫正，建树颇多。除了哈佛医学院，合作伙伴还包括哈佛干细胞研究所、麻省理工学院卫生科学与技术、博德研究所、孤独症联盟和波士顿大学。并且与丹娜法伯癌症研究院、布列根和妇女医院以及麻省总医院保持着紧密的合作关系。
波士顿儿童医院有395张床位，为21岁以下的人群提供全套的医疗服务。每年接纳的病患达到了24，943人次，228个专门临床项目计划每年接纳557，620人次；2012年手术量达到26，534台。
此外, 波士顿儿童医院是世界上最大的以儿童医院为背景的研究机构。研究团队有1100多位科学家，包括9名国家科学院人员、11名医学研究所在职人员和9名霍华休斯医学研究所人员。每年科研投入2亿2千5百万美元，多于任何一家儿童医院。波士顿儿童医院的研究人员John F. Enders为，1954年诺贝尔奖得主，脊髓灰质炎疫苗的奠基人。
波士顿儿童医院享誉全球,拥有璀璨的今天和辉煌的过去。波士顿儿童医院的出色表现不仅在于其手术创新以及新的治疗方法的发现，还在于为儿童提供高质量的医疗并给予儿童高度的关注。
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