Two opening positions of Postdoctoral Research Fellow and visiting scholar are available in Prof. Ke Yuan’s Lab in the Department of Pediatrics at Boston Children’s Hospital/Harvard Medical School.

Both positions utilize cutting-edge interdisciplinary research and aim to understand abnormal vascular remodeling in pulmonary arterial hypertension (PAH) and other pulmonary vascular diseases.The Ke lab will dissect the critical role of pericytes during pulmonary vessel remodeling, by using a combination of cell-based models of angiogenesis, multiple novel inducible transgenic murine models, genome sequencing analysis, in addition to CRISPR gene editing toolkits, 3D spheroid models, precision-cut lung slicing technology, high-resolution deep tissue imaging, and single-cell RNA-seq.Our ultimate goal is to identify potential therapeutic targets that could be exploited for the development of new drugs capable of preventing abnormal vessel remodeling and obliteration in PAH.

Boston Children’s Hospital is ranked the #1 pediatric hospital in the nation by U.S. News and World Report. It is home to the world’s largest pediatric research enterprise, the leading recipient of pediatric research funding from the National Institutes of Health, and the primary pediatric teaching hospital for Harvard Medical School.

Who are we looking for:

Postdoctoral Research Fellow:

Highly motivated Ph.D. with a strong background in> The candidate must also have enthusiasm, excellent critical thinking skills, a track-record of productivity as demonstrated by at least> Prior experience with right ventricular pressure measurements in rodents, primary cell culture, bioinformatics (Single-cell sequencing, ChIP-seq) and data analysis, and CRISPR mediated genome editing would be an advantage.

Research Assistant:

Candidates with Bachelor’s or Master’s degree in Biomedical Sciences or related discipline, Animal handling are preferred; proper attention to details, excellent verbal and written communication skills are prerequisites; experience with rodents, molecular/cell biology, bioinformatics would be an advantage.

What will we offer you:

A successful candidate will have the opportunity to lead independent and cutting-edge research projects with a world-class research facility while obtaining valuable experience with the relevant technology that prepares well for future positions in academia or industry. We will also provide a customizable curriculum, individual career development/support, and Interdisciplinary and collaborative research community.

To apply, please send：

1）a cover letter with a brief statement of research experience and future proposed interests,

2）a detailed curriculum vitae to: Ke Yuan, Ph.D. FAHA

Assistant ProfessorParker B Francis Fellow

Department of Pediatrics

Boston Children’s Hospital/Harvard Medical School

300 Longwood Ave Enders 461.2, Boston, MA 02115

t: 1-617-355-0622

email:ke.yuan@childrens.harvard.edu