A position is available in the Hubbell lab of the Pritzker School of Molecular Engineering at the University of Chicago. The position will focus on using RNA editing to boost the efficacy of immunotherapies.

We are seeking a postdoctoral or visiting scholar researcher who will develop methods to virally deliver RNA editing enzymes and Site-Directed RNA editing reagents into mouse tumor models and then assess tumor progression.

The work will build on novel results obtained through a collaboration between Dr. Jeffrey Hubbell, an expert in Immunotherapies, and Dr. Joshua Rosenthal at the Marine Biological Laboratory, an expert in RNA editing.

Although the position will be primarily based in Chicago, the postdoctoral or visiting scholar researcher will be co-mentored by Drs. Hubbell and Rosenthal and will perform experiments at the Marine Biological Laboratory in Woods Hole, MA as well.

Experimental duties will include engineering recombinant RNA editing enzymes, packaging and delivering RNA editing enzymes and small guide RNAs in viral vectors, and working with mouse cancer models.

The successful candidate will be highly motivated and have a proven track record of conducting independent research.

Broad experience in basic molecular biology techniques is an absolute requirement, and experience using viral delivery systems is highly desirable. In addition, candidates with experience in cancer biology, immunotherapies, synthetic biology or RNA editing are encouraged to apply. 

This position will be expected to demonstrate independence in experimental design and execution, work effectively with others in a collaborative setting, present results at both national and international meetings, and ultimately publish results. in the biological sciences or related disciplines is a prerequisite.

The  will have the opportunity to work with collaborators of the Hubbell and Rosenthal labs and will have a unique opportunity to perform highly original, cross-cutting research between immunotherapy and RNA editing.

This project lies at the interface between basic research and translational biotechnology. For more information on the Hubbell and Rosenthal labs see

1、https://pme.uchicago.edu/group/hubbell-lab 

2、https://www.mbl.edu/bell/current-faculty/joshua-rosenthal/.

Motivated candidates should submit a curriculum vitae and a statement of research goals to

Dr. Jeffrey Hubbell (jhubbell@uchicago.edu) 

and Dr. Joshua Rosenthal (jrosenthal@mbl.edu).

院校简介：

芝加哥大学（简称“芝大”（UChicago），The University of Chicago），于1890年始建，位于美国国际金融中心芝加哥，是世界著名私立研究型大学，常年位列各个大学排行榜世界前十，素以盛产诺贝尔奖得主而闻名。其前身是由美国浸信会建立的一所教会学校。

该校从曼哈顿计划起大批科学家汇集于此，在“原子能之父”费米的领导下建立了世界上第一台核反应堆（芝加哥一号堆）、成功开启人类原子能时代，并创办了美国第一所国家实验室阿贡国家实验室和之后著名的费米实验室，奠定了芝大在自然科学界的重要地位。

芝加哥大学由石油大王约翰·洛克菲勒创办。截止2018年10月，共有98位诺贝尔奖得主在芝大工作或学习过，位列世界第四。华裔诺贝尔物理学奖得主杨振宁、李政道、崔琦均在芝加哥大学取得物理学博士学位，华裔诺贝尔化学奖得主李远哲曾在芝大担任化学教授；另有9位菲尔兹奖得主（世界第七）、4位图灵奖得主及25位普利策奖得主在芝大工作或学习过。

世界上主要有四大权威世界大学排名：

1）世界大学学术排名(ARWU)，该排名完全以客观数据为标准，注重衡量一个大学的学术研究能力而非教学能力；

2）泰晤士高等教育(THE)世界大学排名；

3）QS世界大学排名；

4）usnews世界大学排名（US News Best Global Universities），综合衡量一个大学的学术研究能力和教学能力，侧重研究实力衡量。

其中，2）和3）两项排名是对大学的教学和研究实力地较平均综合衡量，但是易受到一些商业因素和人为主观偏见影响。

四大排名各有优缺点，应综合理想看待。

以下是是芝加哥大学的综合排名情况：

1）2017-18年 ARWU世界大学学术排名：全球第10名

2）2017-18年 THE 泰晤士高等教育世界大学排名：全球第9名，声誉排名：全球第9名

3）2017-18年 QS世界大学排名：全球第9名

4）2017-18年 US NEWS世界大学排名：全球第14名；本科项目排名（Best Colleges），全美第3；

5）2019年6月19日，2020QS世界大学排名发布，芝加哥大学排名第10位。