芝加哥大学（The University of Chicago），简称“芝大”（UChicago），位于美国国际金融中心芝加哥，是世界顶尖私立研究型大学，常年位列各大世界大学排行榜前十。该校诞生了芝加哥经济学派等众多著名的芝加哥学派，创立了法律经济学，是经济学、法学、社会学等学科的世界级学术重镇。
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Positions information：
Our laboratory studies and develops adoptive T cell therapies targeting solid tumors.
The scientist will develop genetically engineered T cells starting from the molecular cloning phase of cell therapy development, and then advancing to preclinical in vitro work and clinically relevant mouse models.
An additional focus will be to develop strategies to recruit neoantigen-targeted immunity.
A strong background in molecular biology and immunology will allow the successful applicant to be creative within the lab, enhancing T cell function and tumor targeting for optimal patient translation and high impact publication.
The scientist will work under the mentorship of lead faculty within the Center for Immunotherapy (CFI), which holds multiple large level grants and houses a highly collaborative group of investigators – including immunologists, molecular biologists, and computational biologists – dedicated to developing immune therapies.
More information on the CFIcan be found here: https://www.roswellpark.org/cancer-care/treatments/immunotherapy/about-cfi/team.
Publications by CFI members directly relevant to active areas of research:
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Cherkassky, L, et al. CAR T cells with cell-intrinsic checkpoint blockade resist tumor-mediated inhibition. Journal of Clinical Investigation, 2016. PMID: 27454297
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Want, M et al. Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer. Oncoimmunology, 2019. PMID: 31069153
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Liu, S, et al. Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer. Journal for ImmunoTherapy of Cancer, 2016. PMID: 31221207
Qualifications:
Requirements are a Ph.D.、 M.D. or a visiting scholar with background in Immunology or Molecular Biology.
Applicants with experience in immune assays, FACS, cell culture, mouse experiments, cell transfections, PCR, and cloning and subcloning into vector constructs are preferred.
An enthusiasm for research investigation and strong work ethic are necessary.
Applicant Instructions:
Interested candidates should provide a CV highlighting previous research work, a brief (<1 page) personal statement, and 3 references.
Inquiries and applications should be sent to Leonid Cherkassky, MD at Leonid.Cherkassky@RoswellPark.org.
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