挪威奥斯陆大学博士后 — 基因编辑和细胞疗法

Postdoctoral Fellow – Gene Editing And Cell-Based Therapy

University Of Oslo

Description

Postdoctoral Fellow – gene editing and cell-based therapy Job description

Are you interested in applying state-of-the-art technologies to develop new treatment possibilities for patients with inherited bleeding disorders?

We are seeking a postdoctoral fellow to join our research team in this exciting project funded by the Norwegian Research Council. The position is affiliated with the Institute of Clinical Medicine, Division of Cancer Medicine at the University of Oslo, but your daily work place will be at Oslo University Hospital, Rikshospitalet. The research group has conducted basic, translational and clinical research for more than 30 years, with a focus on blood coagulation factors and their role in disease.

More about the position

In the project, you will work on a bleeding disorder called inherited factor (F) VII deficiency. FVII is a vital protein in the blood coagulation process and an inherited deficiency of this protein is caused by mutations in the F7 gene leading to severely reduced activity of the FVII protein in the blood. Clinically, these patients experience frequent and sometimes severe bleeding episodes, and the only treatment today is replacement therapy that is expensive and invasive. We are using CRISPR gene editing and advanced cell reprogramming techniques to correct the mutation in the patients’ own cells and establishing transplant procedures in mice models to restore FVII activity and function. These important pre-clinical studies will lay the foundation for cell-based therapies in patient with FVII deficiency.

You will work closely with an experienced researcher on the project and together you will co-supervise a PhD student. The position is over a three- years period.

The main purpose of the fellowship is to qualify researchers for work in higher academic positions within their disciplines.

Qualification requirements

PhD in relevant topic

Ability to independently design, plan, and execute experiments

Formal accreditation (FELISA C or similar) and experience working with mice models (requirement)

Experience in molecular biology techniques such as cell culturing, cloning, qPCR, ELISA, Western blotting, Immunohistochemistry (requirement)

Experience with CRISPR gene editing, stem cell work, and in vivo transplants is an advantage

Proficient in English language, both written and oral

The appointment requires a PhD or a degree equivalent to a Norwegian PhD in natural or medical sciences. A prerequisite for applicants who have not yet defended their thesis is that the thesis is submitted for assessment before the closing date for applications. Appointment to the position is dependent on the public defense of the doctoral thesis being approved.

Personal skills

Excellent communication and team working skills

Organized and structured

Flexible

Willing to learn new methods and techniques

We offer

Salary NOK 534 400 – NOK 594 300 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)

A professionally stimulating working environment

Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

A career development program for postdoctoral fellows The Postdoctoral Programme – Faculty of Medicine (uio.no)

Interest organization for PhD and postdoctoral fellows Home – UiODoc

How to apply

The application must include:

Cover letter (statement of motivation, summarizing scientific work and research interest).

CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activities).

Copies of educational certificates (academic transcripts only).

A complete list of publications.

Any research publications that the applicant wishes to be considered.

List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number).

The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their University’s grading system. Please note that all documents should be in English (or a Scandinavian language).

In assessing the applications, special emphasis will be placed on the documented, academic qualifications, as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.

It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Formal regulations

Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.

No one can be appointed for more than one Postdoctoral Fellow period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. We also want to have employees with diverse expertise, combinations of subjects, life experience and perspectives. We will make adjustments for employees who require this.

If there are qualified applicants with special needs, gaps in their CVs or immigrant backgrounds, we will invite at least one applicant in each of these groups to an interview.

Contact information

Project leader, professor Per Morten Sandset email: p.m.sandset@medisin.uio.no

Researcher, Maria Eugenia CholletDugarte email: m.e.c.dugarte@ous-research.no

Questions regarding the online applicaction form can be adressed to Senior HR Adviser Thoril Kristiansen email: thoril.kristiansen@medisin.uio.no

About the University of Oslo

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty’s educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 800 employees spread over approximately 425 man-labour years, Klinmed is the university’s largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.

Deadline

1st November 2021

Employer

University of Oslo

Municipality

Oslo

Scope

Fulltime (1 jobs) Fulltime (%)

Duration

Temporary

Place of service