英国利兹大学博士后职位— DNA理论物理学

Research Fellow in Theoretical Physics of DNA

University Of Leeds

Description

Research Fellow in Theoretical Physics of DNA

Are you a theoretical physicist interested in tackling biological questions? Would you like to be part of an international multidisciplinary team including microbiologists and computer scientists?

This project will use a mathematical description of DNA to understand the role of supercoiling in genetic control in bacteria. Supercoiling is the torsional stress that occurs in the DNA whenever genes are read or copied. Our hypothesis is that this mechanical distortion enables distant genes to communicate, thereby adding a crucial extra layer of genomic control. You will build a statistical mechanical model of a circular DNA plasmid containing supercoiling sensitive genes to predict the outcome of this genetic circuit when it is expressed in bacteria. Your modelling will be tested experimentally by microbiologists, and formulated into a language for unconventional computing.

You will have a PhD (or you will have submitted your thesis prior to taking up the appointment) in theoretical or computational biophysics, broadly defined. You will also have experience in biophysics modelling, analysis and computational skills and evidence of contributing to papers in internationally recognised, peer-reviewed journals or evidence of publishable research in progress.

To explore the post further or for any queries you may have, please contact:

Dr Sarah Harris, Associate Professor

Tel: +44 (0)113 343 3816 or email: S.A.Harris@leeds.ac.uk