密歇根大学液相色谱-质谱分析和质谱成像博士后研究员

Job Description

The University Of Michigan College Of Pharmacy has 2-3 full-time openings for a research fellow in its Pharmacokinetics and Mass Spectrometry Core Facility (PKMS, www.pkcore.org). In this position, the candidates will learn strategies and techniques for LC-MS analysis, drug optimization and lead drug candidate selection, pharmacokinetics and drug metabolism, clinical sample analysis and clinical pharmacokinetics, and mass spectrometry imaging of small molecules, endogenous metabolites, lipids, proteins on tissue sections.

The successful candidate will independently perform the following research studies:

• LC-MS bioanalysis method development, validation, and samples analysis to clinical studies;
• metabolite identification using LC-MS/MS in microsomal incubation and in vivo biological matrix;
• mass spectrometry imaging of small molecules from tissue samples;
• quantitative LC-MS analysis of compounds in biological matrix of preclinical samples;
• preclinical and clinical pharmacokinetic analysis;
• in vivo animal PK study samples analysis by working with an animal team;
• targeted metabolomics studies for routine quantitation of well-characterized metabolite, or untargeted metabolomics to discover biomarkers;
• independent preparation of study reports.

Required Qualifications

• PhD degree (with 0-3 years experience) in analytical chemistry, chemistry, pharmaceutical sciences, pharmacology, and related field.
• LC-MS skill, knowledge, and experience for small or large molecules are required.
• The candidate should be a good team player with strong oral and written communication skills.

Desired Qualifications

• Knowledge and experience in metabolite identification and pharmacokinetics are preferred.
• Knowledge and experience in high-resolution mass spectrometry, metabolomics, lipidomics, and proteomics are preferred.
• Knowledge and experience in mass spectrometry imaging with MALDI, DESI, and high-resolution mass spectrometry is a plus.
• Ability to work closely with others in a small team setting.

Please send your application to Dr. Bo Wen (wenb@med.umich.edu), Assistant Director of Pharmacokinetics and Mass Spectrometry (PKMS) Core