美国哥伦比亚大学欧文医学中心博士后职位——泌尿生殖系统发育和肿瘤发生的分子机制

Post-doctoral Research Scientist

Columbia University Irving Medical Center

Funded post-doctoral positions are available in the Shen laboratory at Columbia University Irving Medical Center to investigate the molecular mechanisms of genitourinary development and tumorigenesis. We are a dynamic, highly-collaborative group that investigates research topics at the interface of developmental, stem cell, and cancer biology (https://www.genetics.cuimc.columbia.edu/research-labs/shen-lab). We are seeking highly-motivated applicants with a commitment to excellence for studies in the following areas:

1) Genitourinary organogenesis, stem/progenitor cells, and lineage specification. We use genetically-engineered mouse models. single-cell analyses, and systems biology approaches to understand development, regeneration, and repair of the urogenital system, focusing on the prostate. (Wang et al. (2009) Nature 461: 495-500 PMID: 19741607; Talos et al. (2017) Nat. Comm. 8: 14662 PMID: 28429718; Shibata et al. (2020) Stem Cell Rep. 15: 1026-1036 PMID 33176121; Crowley et al. (2020) eLife 9: e59465 PMID 32915138)

2) Prostate cancer initiation, progression, and castration-resistance. We use mouse models, organoid culture, and human tissue samples to elucidate cell types of origin as well as molecular mechanisms of prostate tumorigenesis (Wang et al. (2013) Nat. Cell Biol. 15: 274-283 PMID: 23434823; Wang et al. (2014) Cell Rep. 8: 1339-1346 PMID: 25176651; Chua et al. (2014) Nat. Cell Biol. 16: 951-961 PMID 25241035; Zou et al. (2017) Cancer Discov. 7: 736-749 PMID 28411207; Chua et al. (2018) eLife 7: e28768 PMID: 29334357)

3) Molecular mechanisms of bladder cancer. We use human patient-derived organoid and xenograft models to analyze clonal evolution, drug response, and metastasis in bladder cancer (Lee et al. (2018) Cell 173: 515-528 PMID: 29625057)

Interested candidates should have a Ph.D. degree with a strong background in stem cell biology, developmental biology, and/or cancer research. Expertise with mouse models, organoid culture, imaging, single-cell sequencing, and/or computational biology would be advantageous.

To apply, please send a CV together with a description of research experience and interests, as well as the names of three references to:

Michael M. Shen, Ph.D.

Arthur J. Antenucci Professor of Medical Sciences

Professor of Genetics & Development, Urology, and Systems Biology

Columbia University Irving Medical Center

Herbert Irving Comprehensive Cancer Center

1130 St. Nicholas Ave, room 217B

New York, NY 10032

E-mail: mshen@columbia.edu.

Columbia University is an Equal Opportunity Employer/Disability/Veteran.