美国斯隆—凯特林癌症研究所博士后职位招聘–定量蛋白质组学方面

Applications are invited for several postdoctoral researcher-level positions in Alban Ordureau’s laboratory in the Cell Biology Program at the Sloan Kettering Institute (SKI) in New York City. 

Our lab has exciting projects revolving around kinases, ubiquitin ligases, and overall protein homeostasis signaling (including autophagy). For further details, please see our website: http://ski.edu/ordureau

The successful applicants will deploy a state-of-the-art blend of biochemical, cellular, quantitative proteomics, and genetic methodologies. They will gain experience in understanding signal transduction pathways linked to cellular functions and how they are linked to disease.

We are a dynamic and multidisciplinary group looking to appoint experienced and highly motivated researchers with cutting-edge expertise in one (or more) of the following areas:

1. Mechanistic cell biology focused on understanding and analyzing signal transduction pathways with an emphasis on cellular homeostasis (ubiquitin and autophagy systems). The applicants will employ a multidisciplinary approach, including molecular, biochemical, proteomics, and genetic methodologies such as CRISPR-Cas9 editing. There will be an opportunity to gain experience in proteomics.

2. Biology of stem cell-induced neurons focused on the study of neurological disorders. One of this position’s responsibilities will be to contribute to developing in vitro neuronal differentiation protocols and the production of engineered cells to study neurological disorders. The preferred candidate would have hands-on experience culturing and maintaining undifferentiated iPSC or ESC. Additionally, experience with flow cytometry-based cell sorting and CRISPR-Cas9 editing technology is preferable but not necessary. There will be an opportunity to gain experience in proteomics and biochemistry.

3. Mass spectrometry/analytical chemistry with expertise in quantitative proteomics. Experience in nanoLC-MS/MS and Orbitrap-based mass spectrometers is preferable but not necessary, and training can be provided. Proteomics is central to our research, and to support this, the lab maintains an Eclipse-ETD/UVPD Orbitrap mass spectrometer to conduct a range of quantitative proteomics methods, including TMT, PRM, AHA-methodologies (degradome and translatome) and ubiquitin proteomics.

Experience in proteomics sample preparation (e.g., protein extraction, HPLC separation) and mass-spectrometry technical development is preferred. Some knowledge or desire to learn Python and R and the ability to write and develop scripts and modify/implement open-source or published code is desirable. We are seeking enthusiastic applicants eager to participate and gain experience in conducting biological studies to generate samples and validate data, and training can be provided.

Application Requirements
• Ph.D. with a strong track record and at least two first-authored publications in internationally recognized peer-reviewed journals. Recent Ph.D graduates are encouraged to apply.
• Strong background in either biochemistry, signal transduction, stem cell, molecular biology, or proteomics.
• Capable of working with a diverse team but able to plan and work independently.
• Excellent communication skills.

Application
– For application, please send a CV.

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All incoming postdocs have access to subsidized low-cost housing options for four years. The housing is located within a short distance of research labs.

More details about the various compensation and benefits for SKI post-doc positions can be found here (https://www.mskcc.org/education-training/postdoctoral/resources-postdocs/compensation-benefits-resources).

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Additional information about the Sloan Kettering Institute (SKI):
Sloan Kettering Institute’s research enterprise (http://ski.edu/) is organized into nine programs that encompass the diversity of modern biomedical sciences. SKI investigators pursue research that spans the full spectrum of discovery, from basic science to pre-clinical, translational, and post-clinical research.

The Cell Biology Program at SKI is focused on understanding the molecular mechanisms that control normal cell behavior and how these are disrupted in diseases. Our mission is to identify, through the advancement of knowledge in cell biology, alterations that promote disease progression and new therapeutic opportunities. We carry out much of our work through multidisciplinary collaborations with research groups across SKI and the wider Memorial Sloan Kettering, Weill Cornell Medicine, and the Rockefeller University research community.