巴西圣保罗大学博士后职位招聘–化学、生物物理学、分子生物学、药理学和相关领域

Call for a post-doctoral position

Area of knowledge: Biochemistry

FAPESP process number: 2013/07937-8

Project title: Sun exposure and liposfucinogenisis. A mechanistic in-vitro study

Area of expertise: Biochemistry/Physical-Chemistry, Biophysics

Number of vacancies: 1

Start: 01/Out/2024

Responsible Researcher: Mauricio S. Baptista

Unit/Institution: Chemistry Institute/University of Sao Paulo

Deadline for registration: 09/05/2024

Published: 08/20/2024

Location: Avenida Professor Lineu Prestes, 748. São Paulo-SP

E-mail for registration: [Please click the Apply button for the link or address]

Summary

Postdoctoral fellowship linked to the CEPID Redoxoma (FAPESP). We are looking for candidates with an excellent academic curriculum, background in chemistry, biophysics, molecular biology, pharmacology and related fields with expertise in biochemistry and physiology to study accumulation of lipofuscin in keratynocites in response to visible light (VL) and how this process can be avoided using extrinsic molecules and biological extracts.

The malignant transformation of keratynocites is not yet completely understood, and the effects of blue light exposure have been completely ignored.

[1-2]  We have previously demonstrated that keratynocites accumulate lipofuscin and this process is somohow correlated with the function of lysosomes and the autophagic flux.

[3-5] We will use a combination of biophysics and cellular physiology methods to elucidate the inhibition of the autophagic flux, the accumulation of lipofuscin responding to VL, the signaling consequences in several cell models and test simple chemical and biological extracts that may inhibit this process [6].

Please apply by sending an email with CV and letter of intentions to [Please click the Apply button for the link or address].

References

1. EL Bastos, FH Quina, MS Baptista. Endogenous Photosensitizers in Human Skin. Chemical Reviews 2023, 123 (16), 9720-9785.

2. de Assis, L.V.M., et al., How does the skin sense sun light? An integrative view of light sensing molecules. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 2021. 47:100403.

3. PN Tonolli, CMV Palomino, HC Junqueira, MS Baptista. The phototoxicity action spectra of visible light in HaCaT keratinocytes. Journal of Photochemistry and Photobiology B: Biology 2023, 243, 112703.

4. PN Tonolli, O Chiarelli-Neto, C Santacruz-Perez, HC Junqueira, IS Watanabe, FG Ravagnani, WK Martins, MS Baptista. Lipofuscin generated by UVA turns keratinocytes photosensitive to visible light. The Journal of investigative dermatology 2017, 137 (11), 2447-2450.

5. WK Martins, NF Santos, CS Rocha, IOL Bacellar, TM Tsubone, AC Viotto, AY Matsukuma, ABP Abrantes, P Siani, LG Dias, MS Baptista. Parallel damage in mitochondria and lysosomes is an efficient way to photoinduce cell death. Autophagy 2019, 15 (2), 259-279.

6. D Rodrigues, AC Viotto, R Checchia, A Gomide, D Severino, R Itri, Baptista MS and Martins W. Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage Photochemical & Photobiological Sciences 2016, 15 (3), 334-350